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Hb D-Iran

Profile card
Created on 2025/06/10

General information

Globin chain involved

Beta-globin

Status

Heterozygous

Migration zones

Z(D)

Migration positions

200

Sickle Cell Disease: No

Thalassemic variant: No

Capillary Electrophoresis

Fractions

Value %

Hb A

55.2

Hb D-Iran

42.9

Hb A2

1.9

Comments

In the presence of Hb D-Iran, the percentage of Hb A2 is generally slightly decreased, just below 2.0%.

Mutation data

Heterozygous Hb D-Iran

Mutation

HGVS Nomenclature

Beta 22(B4) Glu>Gln

HBB:c.67G>C

Hematological parameters

Name

Result

RBC Count

Normal

Total Hemoglobin

Normal

MCV

Low

MCH

Normal

Blood smear

Normal

Other analysis

No information

Comments on hematology

Normal

Clinical context

Clinical presentation

Normal

Clinical risk

No data

Variant information

Stability

Normal

Oxygen affinity

Normal

Ethnicities in literature

Found in Asian, Black African & Caucasian populations: met in several Iranian families, in a 25-year-old Pakistani female and relatives, in some Indian families, in a Jamaican Black newborn of West African ancestry living in the US, in some Algerian & Turkish families, and some families in Northern Calabria, Italy

Comments on variant information

The rare variant Hb D-Iran has been found in combination with Hb S (benign Sickle Cell Syndrome), Hb D-Punjab, Beta0-thalassemia (619 bp deletion), Beta0-thalassemia IVS1-5 (G>C), Beta0-thalassemia [cds 41/42 (-CTTT)], and also in homozygous state.

Scientific Literature

  • Hb A2'

    ,

    Hb B2

  • Hb A2-Babinga

  • Hb A2-Coburg

  • Hb Abruzzo

  • Hb Andrew-Minneapolis

  • Hb Arta + Beta0-thalassemia Codon 39

  • Hb Arya

  • Hb Aubagne

  • Hb Bassett

  • Hb Beograd

    ,

    Hb D-Camperdown

  • Hb Bougardirey-Mali

  • Hb Brest

  • Hb Bruxelles

  • Hb Camperdown

  • Hb Chad

    ,

    Hb E-Keelung

  • Hb C-Harlem

    ,

    Hb C-Georgetown

  • Hb C-Harlem + Alpha+-thalassemia

    ,

    Hb C-Georgetown

  • Hb Cocody

  • Hb Cook

  • Hb Créteil

  • Hb C-Ziguinchor

  • Hb D-Iran

  • Hb Djelfa

  • Hb El Escorial

  • Hb E-Saskatoon

No hemoglobin profiles found

Migration zones

Migration position

1 to 300

Mutation types

Sickle Cell Disease

New Case & Recently Updated