Atlas Hemoglobin
Hemoglobinopathies
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Hb C-Harlem

Hb C-Georgetown

Profile card
Created on 2010/05/26
Updated on 2025/05/16

General information

Globin chain involved

Beta-globin

Status

Heterozygous

Migration zones

Z(C)

Migration positions

251

Sickle Cell Disease: Yes

Thalassemic variant: No

Capillary Electrophoresis

Fractions

Value %

Hb A

46.8

Hb A2

4.6

Hb C-Harlem

48.6

Comments

The high percentage of Hb A2 has not been elucidated.

Mutation data

Heterozygous Hb C-Harlem

Mutation

HGVS Nomenclature

Beta 6(A3) Glu>Val and Beta 73(E17) Asp>Asn

HBB:c.[20A>T;220G>A]

Hematological parameters

Name

Result

RBC Count

No information

Total Hemoglobin

No information

MCV

No information

MCH

No information

Blood smear

No information

Other analysis

No information

Comments on hematology

Normal

Clinical context

Clinical presentation

Normal

Clinical risk

This rare variant causes Sickle Cell Disease in association with Hb S. This variant is classified as a non-Hb S Sickling variant

  • Hb A2'

    ,

    Hb B2

  • Hb A2-Babinga

  • Hb A2-Coburg

  • Hb Abruzzo

  • Hb Andrew-Minneapolis

  • Hb Arta + Beta0-thalassemia Codon 39

  • Hb Arya

  • Hb Aubagne

  • Hb Bassett

  • Hb Beograd

    ,

    Hb D-Camperdown

  • Hb Bougardirey-Mali

  • Hb Brest

  • Hb Bruxelles

  • Hb Camperdown

  • Hb Chad

    ,

    Hb E-Keelung

  • Hb C-Harlem

    ,

    Hb C-Georgetown

  • Hb C-Harlem + Alpha+-thalassemia

    ,

    Hb C-Georgetown

  • Hb Cocody

  • Hb Cook

  • Hb Créteil

  • Hb C-Ziguinchor

  • Hb D-Iran

  • Hb Djelfa

  • Hb El Escorial

  • Hb E-Saskatoon

No hemoglobin profiles found

Migration zones

Migration position

1 to 300

Mutation types

Sickle Cell Disease

New Case & Recently Updated